abstract：AIM:To investigate survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis in the antiviral era. METHODS:We used the Korean Health Insurance Review and Assessment. Korea's health insurance system is a public single-payer system. The study population consisted of 286871 pa...

journal_title：World journal of gastroenterology

authors： Ju YC,Jun DW,Choi J,Saeed WK,Lee HY,Oh HW

更新日期：2018-10-28 00:00:00

abstract：:[This corrects the article on p. 1107 in vol. 21, PMID: 26640344.]. ...

journal_title：World journal of gastroenterology

authors： Tong YF,Cai XJ

更新日期：2018-10-21 00:00:00

abstract：AIM:To investigate the potential effect of inhibitors of phosphodiesterase-5 (PDE-5) for therapy of portal hypertension in liver cirrhosis. METHODS:In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway was investigated. Expression and local...

journal_title：World journal of gastroenterology

authors： Schaffner D,Lazaro A,Deibert P,Hasselblatt P,Stoll P,Fauth L,Baumstark MW,Merfort I,Schmitt-Graeff A,Kreisel W

更新日期：2018-10-14 00:00:00

abstract：AIM:To investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity. METHODS:A total of 338 chronic hepatitis B (CHB) patients were divided into a disease group (patients with hepatic fibrosis) and control group (subjects without hepatic fib...

journal_title：World journal of gastroenterology

authors： Xu B,Zhou NM,Cao WT,Li XJ

更新日期：2018-10-07 00:00:00

abstract：:Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years ...

journal_title：World journal of gastroenterology

authors： Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A

更新日期：2018-09-28 00:00:00

abstract：AIM:To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS:In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophago...

journal_title：World journal of gastroenterology

authors： Toyoshima O,Nishizawa T,Sakitani K,Yamakawa T,Takahashi Y,Yamamichi N,Hata K,Seto Y,Koike K,Watanabe H,Suzuki H

更新日期：2018-09-21 00:00:00

abstract：AIM:To investigate the role of Delta-like ligand 4 (DLL4) on tumour growth in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) in vivo. METHODS:We suppressed DLL4 expression in an HBV expressing HCC cell line, HepG2.2.15 and analysed the growth ability of cells as subcutaneous tumours in nude mice. Th...

journal_title：World journal of gastroenterology

authors： Kunanopparat A,Issara-Amphorn J,Leelahavanichkul A,Sanpavat A,Patumraj S,Tangkijvanich P,Palaga T,Hirankarn N

更新日期：2018-09-14 00:00:00

abstract：AIM:To establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research including biomarker testing and drug response prediction. METHODS:Cell line establishment was conducted from dir...

journal_title：World journal of gastroenterology

authors： Gock M,Mullins CS,Harnack C,Prall F,Ramer R,Göder A,Krämer OH,Klar E,Linnebacher M

更新日期：2018-09-07 00:00:00

abstract：AIM:To explore the relationship between dynamic expression of high mobility group box-3 (HMGB3) and malignant transformation of hepatocytes. METHODS:Expression of HMGB family proteins were observed in rat hepatocarcinogenesis models induced with 2-acetylaminofluorene. Alterations of HMGB3 were analyzed at the mRNA lev...

journal_title：World journal of gastroenterology

authors： Zheng WJ,Yao M,Fang M,Wang L,Dong ZZ,Yao DF

更新日期：2018-08-28 00:00:00

abstract：AIM:To investigate the expression and clinical significance of B7 homolog 3 (B7-H3) and β-1,3-galactosyltransferase-4 (B3GALT4) in colorectal cancer (CRC) patients. METHODS:Using tissue microarray, we identified the expression of B7-H3 and B3GALT4 in 223 CRC patient samples by immunohistochemistry and evaluated the po...

journal_title：World journal of gastroenterology

authors： Zhang T,Wang F,Wu JY,Qiu ZC,Wang Y,Liu F,Ge XS,Qi XW,Mao Y,Hua D

更新日期：2018-08-21 00:00:00

abstract：AIM:To explore the role and mechanism of total flavone of Abelmoschus manihot (TFA) on epithelial-mesenchymal transition (EMT) progress of Crohn's disease (CD) intestinal fibrosis. METHODS:First, CCK-8 assay was performed to assess TFA on the viability of intestinal epithelial (IEC-6) cells and select the optimal conc...

journal_title：World journal of gastroenterology

authors： Yang BL,Zhu P,Li YR,Xu MM,Wang H,Qiao LC,Xu HX,Chen HJ

更新日期：2018-08-14 00:00:00

abstract：AIM:To assess the efficacy and safety of fourth-generation quinolones for Helicobacter pylori (H. pylori) eradication, we conducted this systematic review and meta-analysis of randomized clinical trials. METHODS:Major literature databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) were sea...

journal_title：World journal of gastroenterology

authors： An Y,Wang Y,Wu S,Wang YH,Qian X,Li Z,Fu YJ,Xie Y

更新日期：2018-08-07 00:00:00

abstract：AIM:To evaluate the prognostic power of different molecular data in liver cancer. METHODS:Cox regression screen and least absolute shrinkage and selection operator were performed to select significant prognostic variables. Then the concordance index was calculated to evaluate the prognostic power. For the combination ...

journal_title：World journal of gastroenterology

authors： Song YZ,Li X,Li W,Wang Z,Li K,Xie FL,Zhang F

更新日期：2018-07-28 00:00:00

abstract：AIM:To evaluate the long-term efficacy of endoscopic resection (ER) for small (≤ 4.0 cm) gastric gastrointestinal stromal tumors (GISTs) originating from the muscularis propria layer. METHODS:Between June 2005 and February 2015, we retrospectively analyzed 229 consecutive patients with gastric MP-GISTs who underwent E...

journal_title：World journal of gastroenterology

authors： Zhang Y,Mao XL,Zhou XB,Yang H,Zhu LH,Chen G,Ye LP

更新日期：2018-07-21 00:00:00

abstract：:Pancreatic cystic lesions (PCLs) are increasingly being identified because of the widespread use of high-resolution abdominal imaging. These cysts encompass a spectrum from malignant disease to benign lesions, and therefore, accurate diagnosis is crucial to determine the best management strategy, either surgical resec...

journal_title：World journal of gastroenterology

authors： Alvarez-Sánchez MV,Napoléon B

更新日期：2018-07-14 00:00:00

abstract：AIM:To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis (TB) infection in Crohn's disease (CD) patients treated with tumor necrosis factor-alpha (TNFα) inhibitors. METHODS:A meta-analysis of randomized, double-blind, placebo-controlled trials of TNFα inhibitors for treatment of CD in adults...

journal_title：World journal of gastroenterology

authors： Cao BL,Qasem A,Sharp RC,Abdelli LS,Naser SA

更新日期：2018-07-07 00:00:00

abstract：:Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among ...

journal_title：World journal of gastroenterology

authors： Meng XF,Pan YW,Wang ZB,Duan WD

更新日期：2018-06-28 00:00:00

abstract：AIM:To compare the efficacy, improved quality of life, and prognosis in patients undergoing either subtotal colonic bypass with antiperistaltic cecoproctostomy (SCBAC) or subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy (SCBCAC) for the treatment of slow transit constipation. METHODS:Between...

journal_title：World journal of gastroenterology

authors： Yang Y,Cao YL,Wang WH,Zhang YY,Zhao N,Wei D

更新日期：2018-06-21 00:00:00

abstract：AIM:To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures. METHODS:A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation comb...

journal_title：World journal of gastroenterology

authors： Szapáry L,Tinusz B,Farkas N,Márta K,Szakó L,Meczker Á,Hágendorn R,Bajor J,Vincze Á,Gyöngyi Z,Mikó A,Csupor D,Hegyi P,Erőss B

更新日期：2018-06-07 00:00:00

abstract：AIM:To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width (RDW) in esophageal cancer (EC). METHODS:We searched the PubMed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA v...

journal_title：World journal of gastroenterology

authors： Xu WY,Yang XB,Wang WQ,Bai Y,Long JY,Lin JZ,Xiong JP,Zheng YC,He XD,Zhao HT,Sang XT

更新日期：2018-05-21 00:00:00

abstract：:Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and ...

journal_title：World journal of gastroenterology

authors： Shen Y,Li J,Wang SQ,Jiang W

更新日期：2018-05-14 00:00:00

abstract：:Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack...

journal_title：World journal of gastroenterology

authors： Mukaida N,Nakamoto Y

更新日期：2018-05-07 00:00:00

abstract：AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...

journal_title：World journal of gastroenterology

authors： Gong SS,Fan YH,Wang SY,Han QQ,Lv B,Xu Y,Chen X,He YE

更新日期：2018-04-28 00:00:00

abstract：AIM:To determine short- and long-term outcomes of endoscopic submucosal dissection (ESD) using the stag beetle (SB) knife, a scissor-shaped device. METHODS:Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, betwee...

journal_title：World journal of gastroenterology

authors： Kuwai T,Yamaguchi T,Imagawa H,Miura R,Sumida Y,Takasago T,Miyasako Y,Nishimura T,Iio S,Yamaguchi A,Kouno H,Kohno H,Ishaq S

更新日期：2018-04-21 00:00:00

abstract：:Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most ...

journal_title：World journal of gastroenterology

authors： Losurdo G,Principi M,Iannone A,Amoruso A,Ierardi E,Di Leo A,Barone M

更新日期：2018-04-14 00:00:00

abstract：:Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver transplantation (LT), platelet count decreases and reaches a nadir on postoperative days 3-5, with an average reduction in platelet counts of 60%; platelet count recovers to preoperative levels approximately two weeks after LT. ...

journal_title：World journal of gastroenterology

authors： Takahashi K,Nagai S,Safwan M,Liang C,Ohkohchi N

更新日期：2018-04-07 00:00:00

abstract：AIM:To analyze the safety and efficiency of direct-acting antiviral (DAA) regimens in liver-transplanted patients with hepatitis C virus (HCV) reinfection. METHODS:Between January 2014 and December 2016, 39 patients with HCV reinfection after liver transplantation were treated at our tertiary referral center with sofo...

journal_title：World journal of gastroenterology

authors： Rupp C,Hippchen T,Neuberger M,Sauer P,Pfeiffenberger J,Stremmel W,Gotthardt DN,Mehrabi A,Weiss KH

更新日期：2018-03-28 00:00:00

abstract：AIM:To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells (PBMCs) from Crohn's disease (CD) patients in clinical remission. METHODS:Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding ...

journal_title：World journal of gastroenterology

authors： Schäffler H,Rohde M,Rohde S,Huth A,Gittel N,Hollborn H,Koczan D,Glass Ä,Lamprecht G,Jaster R

更新日期：2018-03-21 00:00:00

abstract：AIM:To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicr...

journal_title：World journal of gastroenterology

authors： Lord R,Burr NE,Mohammed N,Subramanian V

更新日期：2018-03-14 00:00:00

abstract：:Two-dimensional shear wave elastography (2D-SWE) is a rapid, simple and novel noninvasive method that has been proposed for assessing hepatic fibrosis in patients with chronic liver diseases (CLDs) based on measurements of liver stiffness. 2D-SWE can be performed easily at the bedside or in an outpatient clinic and yi...

journal_title：World journal of gastroenterology

authors： Xie LT,Yan CH,Zhao QY,He MN,Jiang TA

更新日期：2018-03-07 00:00:00

abstract：AIM:To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS:This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were...

journal_title：World journal of gastroenterology

authors： Rubio-Manzanares Dorado M,Marín Gómez LM,Aparicio Sánchez D,Pereira Arenas S,Praena-Fernández JM,Borrero Martín JJ,Farfán López F,Gómez Bravo MÁ,Muntané Relat J,Padillo Ruiz J

更新日期：2018-02-21 00:00:00

abstract：AIM:To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps (< 10 mm). METHODS:A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 y...

journal_title：World journal of gastroenterology

authors： Menees SB,Kim HM,Schoenfeld P

更新日期：2018-02-14 00:00:00

abstract：AIM:To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS:A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with ...

journal_title：World journal of gastroenterology

authors： Marcon PDS,Tovo CV,Kliemann DA,Fisch P,de Mattos AA

更新日期：2018-02-07 00:00:00

abstract：AIM:To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS:Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18F-FDG PET/CT for measuring tumour glucose uptake were performed in...

journal_title：World journal of gastroenterology

authors： Li YC,Yang CS,Zhou WL,Li HS,Han YJ,Wang QS,Wu HB

更新日期：2018-01-28 00:00:00

abstract：AIM:To evaluate the clinical advantages of single-port laparoscopic hepatectomy (SPLH) compare to multi-port laparoscopic hepatectomy (MPLH). METHODS:We retrospectively reviewed the medical records of 246 patients who underwent laparoscopic liver resection between January 2008 and December 2015 at our hospital. We div...

journal_title：World journal of gastroenterology

authors： Han JH,You YK,Choi HJ,Hong TH,Kim DG

更新日期：2018-01-21 00:00:00

abstract：AIM:To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients. METHODS:Four IFR5 SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/...

journal_title：World journal of gastroenterology

authors： Sy BT,Hoan NX,Tong HV,Meyer CG,Toan NL,Song LH,Bock CT,Velavan TP

更新日期：2018-01-14 00:00:00

abstract：AIM:To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism. METHODS:SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic hist...

journal_title：World journal of gastroenterology

authors： Li J,Zhou R,Bie BB,Huang N,Guo Y,Chen HY,Shi MJ,Yang J,Zhang J,Li ZF

更新日期：2018-01-07 00:00:00

abstract：AIM:To define probiotic monotherapy effect on Helicobacter pylori (H. pylori) status by performing a systematic review. METHODS:Methods of analysis and inclusion criteria were based on PRISMA recommendations. Relevant publications were identified by searching PubMed, MEDLINE, Science Direct, and EMBASE. The end-point ...

journal_title：World journal of gastroenterology

authors： Losurdo G,Cubisino R,Barone M,Principi M,Leandro G,Ierardi E,Di Leo A

更新日期：2018-01-07 00:00:00

abstract：AIM:To determine the prevalence, characteristics and clinical course of pancreatic cystic neoplasms (PCNs) in liver transplantation (LT) recipients. METHODS:We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medic...

journal_title：World journal of gastroenterology

authors： Liu K,Joshi V,van Camp L,Yang QW,Baars JE,Strasser SI,McCaughan GW,Majumdar A,Saxena P,Kaffes AJ

更新日期：2017-12-28 00:00:00

abstract：AIM:To assess the cleansing efficacy and safety of a new Colon capsule endoscopy (CCE) bowel preparation regimen. METHODS:This was a multicenter, prospective, randomized, controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system (Pi...

journal_title：World journal of gastroenterology

authors： Kastenberg D,Burch WC Jr,Romeo DP,Kashyap PK,Pound DC,Papageorgiou N,Sainz IF,Sokach CE,Rex DK

更新日期：2017-12-28 00:00:00